Modifier genes for sudden cardiac death

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Sudden Cardiac Death, Genes, and Arrhythmogenesis

Malignant ventricular arrhythmias are the leading mechanism of death in patients with acute and chronic cardiac pathologies. The extent to which inherited mutations and polymorphic variation in genes determining arrhythmogenic mechanisms affect these patients remains unknown, but based on recent population studies, this risk appears significant, deserving much greater investigation. This report...

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From the Section of Electrophysiology, Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA (R.D.); Division of Preventive Medicine and Cardiovascular Medicine, Center for Arrhythmia Prevention, Brigham and Women’s Hospital, Boston, MA (C.M.A.). Correspondence to Christine M. Albert, MD, MPH, Division of Preventive Medicine and Cardiovascular Medicine, Center for Ar...

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Sudden cardiac death (SCD) in a young athlete commonly brings to the forefront the many gaps in knowledge regarding how to predict and prevent these rare tragic events.1–3 Although the number of athletic sudden deaths is relatively small, with 100 to 150 competitive deaths during sports in the United States annually, they represent an important and emotionally charged public health issue, perha...

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Why are we not doing more to prevent sudden unexpected cardiac death? Why is prevention of the principal cause of death occurring during acute myocardial ischaemia and impending myocardial infarction ignored? The majority are caused by ventricular fibrillation. This is most common within the first hour after the onset of an acute coronary syndrome and occurs with decreasing frequency thereafter...

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Sudden cardiac death -- 1978.

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ژورنال

عنوان ژورنال: European Heart Journal

سال: 2018

ISSN: 0195-668X,1522-9645

DOI: 10.1093/eurheartj/ehy502